Codeine Within an embryofetal advancement analyze in pregnant rats dosed all through the duration of organogenesis, codeine elevated resorptions and lowered fetal weights in a dose approximately 25 periods the MRHD (with a mg/m2 basis using a maternal oral dose of a hundred and twenty mg/kg/day); even so, these effects occurred in the existence of maternal toxicity.
Promethazine HCl Oral Answer is contraindicated in comatose states, As well as in people today identified for being hypersensitive or to acquire had an idiosyncratic response to promethazine or to other phenothiazines.
are Expecting or strategy to become pregnant. Promethazine Hydrochloride and Codeine Phosphate Oral Remedy can harm your unborn little one. See “What exactly is The main details I should understand about Promethazine Hydrochloride and Codeine Phosphate Oral Resolution?” are breastfeeding or plan to breastfeed. Codeine passes into your breast milk and could cause major Unwanted side effects as part of your child such as amplified sleepiness, breathing issues (respiratory melancholy), and Dying. It's not necessarily identified if promethazine can move into your breast milk.
Antihistamines are contraindicated to be used during the procedure of lower respiratory tract symptoms, which includes asthma.
Promethazine HCl Oral Answer really should be made use of with warning in patients with bone-marrow depression. Leukopenia and agranulocytosis have already been described, ordinarily when Promethazine (Promethazine HCl) is used in association with other recognized marrow-toxic agents.
Head Damage And Enhanced Intracranial Pressure: The respiratory-depressant effects of narcotic analgesics as well as their potential to elevate cerebrospinal fluid force can be markedly exaggerated during the presence of head damage, intracranial lesions or maybe a preexisting increase in intracranial tension.
Promethazine is undoubtedly an H1 receptor blocking agent. As well as its antihistaminic motion, it provides clinically useful sedative and antiemetic consequences.
Recommend patients to generally use an accurate milliliter measuring product when measuring and administering Promethazine HCl and Codeine Phosphate Oral Resolution. Advise individuals that a residence teaspoon isn't an precise measuring product and this sort of use could lead to overdosage and severe adverse reactions [see Overdosage (ten)].
Promethazine HCl Oral Solution is contraindicated in comatose states, and in persons regarded to get hypersensitive or to own had an idiosyncratic response to Promethazine or to other phenothiazines.
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Thought needs to be given to your discontinuation of Promethazine HCl and to using other medications if these reactions take place. Respiratory despair, nightmares, delirium, and agitated conduct have also been claimed in A few of these people.
Overdose of codeine in Older people has been connected with deadly respiratory melancholy, and using codeine in small children youthful than 12 decades of age has actually been connected with lethal respiratory depression when utilised as advisable [see Warnings and Precautions read more (5.
Codeine wasn't mutagenic in the in vitro bacterial reverse mutation assay or clastogenic during the in vitro Chinese hamster ovary (CHO) mobile chromosomal aberration assay.
Your healthcare provider may perhaps do blood assessments to check for adrenal gland complications. Simply call your healthcare provider at once if you have any of those signs: